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尊龙凯时胃肠胶囊维持胚胎小白鼠小肠组织植块存活及重新组合成粘膜组织
[摘 要]：目的：通过体外检测尊龙凯时胃肠胶囊（GIC）对胚胎小白鼠小肠器官型植块生长的作用以探索GIC修复粘膜损伤的机理。方法：体外培养胚胎小白鼠小肠器官型植块，并将所有植块分为两组：实验组和对照组。结果：实验组的小肠器官型植块能很好地维持存活，并有大量的单个细胞、细胞克隆以及片状粘膜组织块长出，生长的时间长，生长状态好；而对照组的小肠器官型植块均很快归于死亡。二者差异极为显著。结论：GIC能够维持胚胎小白鼠小肠器官型植块的存活，并能促进细胞增殖，某种程度上维持组织的完整性，重新组合成粘膜组织，此结果可能与GIC激活上皮干细胞有关。
[关键词]：GIC；小肠植块；生长
GIC Could Maintain
Survival and Promote Cell Growth of Organ-Type Explants of Intestine
of Mouse Embryo Xu rong-xiang,Wang Yan-ping,Fan Ran,etc。
Central laboratory, MEBO
Global Group 100053
[Abstract]：
Objective:
To research on the reparative mechanism of GIC on intestinal lesion
through examining the effect of on the survival and cell growth
of organ-type explants of intestinal tissue of mouse embryo.
Methods: Cultured the organ-type explants of mouse intestinal
tissue in vitro, all the explants were divided into two groups:
test group and control group.
Results: Explants could survive in test group. Single cells,
cell clones and tissue pieces could grew out of the explants and
grew long and well in test group. Conclusion: could maintain
survival of intestinal explants and promote growth of cells from
intestinal explants of mouse embryo and this process may be involved
in the activation of epithelial stem cells.
[Key words]： GIC;
intestinal explant ; growth
大量临床实践显示，GIC可能也是通过激活粘膜上皮干细胞、促进组织细胞生长的机理实现对损伤粘膜修复的，为了证明这一观点，我们特设计了本实验。
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